Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have …
associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have …
Inhibitors of bacterial immune systems: discovery, mechanisms and applications
D Mayo-Muñoz, R Pinilla-Redondo… - Nature Reviews …, 2024 - nature.com
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
H Morisaka, K Yoshimi, Y Okuzaki, P Gee… - Nature …, 2019 - nature.com
Although single-component Class 2 CRISPR systems, such as type II Cas9 or type V
Cas12a (Cpf1), are widely used for genome editing in eukaryotic cells, the application of …
Cas12a (Cpf1), are widely used for genome editing in eukaryotic cells, the application of …
[HTML][HTML] Anti-CRISPR phages cooperate to overcome CRISPR-Cas immunity
Some phages encode anti-CRISPR (acr) genes, which antagonize bacterial CRISPR-Cas
immune systems by binding components of its machinery, but it is less clear how …
immune systems by binding components of its machinery, but it is less clear how …
Anti-CRISPRs: protein inhibitors of CRISPR-Cas systems
Clustered regularly interspaced short palindromic repeats (CRISPR) together with their
accompanying cas (CRISPR-associated) genes are found frequently in bacteria and …
accompanying cas (CRISPR-associated) genes are found frequently in bacteria and …
Anti-CRISPR-associated proteins are crucial repressors of anti-CRISPR transcription
Phages express anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems that would
otherwise destroy their genomes. Most acr genes are located adjacent to anti-CRISPR …
otherwise destroy their genomes. Most acr genes are located adjacent to anti-CRISPR …
Phage-encoded anti-CRISPR defenses
SY Stanley, KL Maxwell - Annual review of genetics, 2018 - annualreviews.org
The battle for survival between bacteria and bacteriophages (phages) is an arms race where
bacteria develop defenses to protect themselves from phages and phages evolve …
bacteria develop defenses to protect themselves from phages and phages evolve …
The diverse impacts of phage morons on bacterial fitness and virulence
VL Taylor, AD Fitzpatrick, Z Islam, KL Maxwell - Advances in virus research, 2019 - Elsevier
The viruses that infect bacteria, known as phages, are the most abundant biological entity on
earth. They play critical roles in controlling bacterial populations through phage-mediated …
earth. They play critical roles in controlling bacterial populations through phage-mediated …
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
Among the multiple antiviral defense mechanisms found in prokaryotes, CRISPR-Cas
systems stand out as the only known RNA-programmed pathways for detecting and …
systems stand out as the only known RNA-programmed pathways for detecting and …
The application of the CRISPR-Cas system in antibiotic resistance
S Tao, H Chen, N Li, W Liang - Infection and drug resistance, 2022 - Taylor & Francis
The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …
threat to global public health in recent years. AMR genes are shared between bacterial …