The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new
challenges and opportunities for understanding the physiology, pathophysiology, and …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

In modern society, cardiovascular disease remains the biggest single threat to life, being
responsible for approximately one third of worldwide deaths. Male prevalence is significantly …

The G protein–coupled estrogen receptor (GPER) mediates both the genomic and
nongenomic effects of estrogen and has been implicated in breast cancer development …

Three types of estrogen receptors (ER) exist in the heart, Esr1, Esr2 and the G protein-
coupled estrogen receptor 1, Gper1. However, their relative importance in mediating …

Chronic kidney disease has a tremendously increasing prevalence and requires novel
therapeutic approaches. Mineralocorticoid receptor (MR) antagonists have proven highly …

Increasing levels of estrogens across gestation are partly responsible for the physiological
adaptations of the maternal vasculature to pregnancy. The G protein-coupled estrogen …

The mineralocorticoid aldosterone is a key regulator of water and electrolyte homeostasis.
Numerous recent developments have advanced the field of mineralocorticoid pharmacology …

Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called
Raynaud's phenomenon (RP). Interestingly, RP is significantly more prevalent in females …

Estrogen exerts protective effects against cardiovascular diseases in premenopausal
women, but is associated with an increased risk of both coronary heart disease and stroke in …