The active state of centromeres is epigenetically defined by the presence of CENP-A
interspersed with histone H3 nucleosomes. While the importance of dimethylation of H3K4 …

Hematopoietic stem cells (HSCs) drive cellular turnover in the hematopoietic system by
balancing self-renewal and differentiation. In the adult bone marrow (BM), these cells are …

RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of
small GTPases. It is highly expressed in hematopoietic cells but is also present in a large …

Cell-cell contact formation of polarized epithelial cells is a multi-step process that involves
the co-ordinated activities of Rho family small GTPases. Consistent with the central role of …

Dysfunction of the centrosome, the major microtubule-organizing center of the cell, is
implicated in microcephaly. Haploinsufficiency of mixed-lineage leukemia (MLL/KMT2A) …

RhoA, Rac1 and CDC42 are small G proteins that play a crucial role in regulating various
cellular processes, such as the formation of actin cytoskeleton, cell shape and cell migration …

Papillary thyroid carcinoma (PTC) is a common endocrine malignancy. The pathology of
PTC is far from clear. As a kinase that can be targeted, the role of TNIK in PTC has not been …

ABSTRACT The 43rd Annual Conference of the Indian Association of Cancer Research
(IACR) was held between 19th and 22nd January 2024 at the Indian Institute of Education …

Trimethylation of histone 3 lysine 4 (H3K4me3) is mark of active transcription and its
regulatory role in RNA polymerase II-mediated transcription has been well-studied …

Mixed-lineage leukemia (MLL) protein is a well characterized epigenetic regulator whose
non-canonical activities remain under appreciated. Here we show that MLL and its …