Arterial pulsations drive oscillatory flow of CSF but not directional pumping

RT Kedarasetti, PJ Drew, F Costanzo - Scientific reports, 2020 - nature.com
The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a
“glymphatic system” where metabolites are removed from the brain's extracellular space by …

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model

RT Kedarasetti, PJ Drew, F Costanzo - Fluids and Barriers of the CNS, 2022 - Springer
The movement of fluid into, through, and out of the brain plays an important role in clearing
metabolic waste. However, there is controversy regarding the mechanisms driving fluid …

Functional hyperemia drives fluid exchange in the paravascular space

RT Kedarasetti, KL Turner, C Echagarruga… - Fluids and Barriers of …, 2020 - Springer
The brain lacks a conventional lymphatic system to remove metabolic waste. It has been
proposed that directional fluid movement through the arteriolar paravascular space (PVS) …

Twofold saddle-point formulation of Biot poroelasticity with stress-dependent diffusion

B Gómez-Vargas, KA Mardal, R Ruiz-Baier… - SIAM Journal on …, 2023 - SIAM
We present a new stress/total-pressure formulation for poroelasticity that incorporates the
coupling with steady nonlinear diffusion modified by stress. This nonlinear problem is written …

Coupling chemotaxis and growth poromechanics for the modelling of feather primordia patterning

NA Barnafi, LM De Oliveira Vilaca, MC Milinkovitch… - Mathematics, 2022 - mdpi.com
In this paper we propose a new mathematical model for describing the complex interplay
between skin cell populations with fibroblast growth factor and bone morphogenetic protein …

Numerical analysis for an energy-stable total discretization of a poromechanics model with inf-sup stability

B Burtschell, P Moireau, D Chapelle - Acta Mathematicae Applicatae …, 2019 - Springer
We consider a previously proposed general nonlinear poromechanical formulation, and we
derive a linearized version of this model. For this linearized model, we obtain an existence …

A mixture theory-based finite element formulation for the study of biodegradation of poroelastic scaffolds

P Patki, F Costanzo - Computational Mechanics, 2020 - Springer
Surgical implants, known as Tissue Engineered Nerve Guides (TENGs) are often inserted to
provide alignment and mechanical support to broken or damaged nerves. These implants …

[HTML][HTML] Numerical simulation of the pressing of polycrystalline diamond compact cutter into the rock based on arbitrary Lagrangian-Eulerian algorithm

Y Zeng, L Sun, K Wei, Y Wang, F Zhang… - Alexandria Engineering …, 2020 - Elsevier
For the polycrystalline diamond compact (PDC) bit, the first step of rock breaking is to press
the bit into the rock. However, it is very difficult to theorize the pressing process, due to the …

[图书][B] Drivers of Fluid and Metabolite Transport in the Central Nervous System

RT Kedarasetti - 2021 - search.proquest.com
The brain is one of the most metabolically active organs in the mammalian body. For proper
brain function, the metabolic waste has to be removed continuously. Accumulation of …

[PDF][PDF] Modeling Fluid-Structure Interaction of Biodegradation in Engineered Tissue Scaffolds

P Patki, F Costanzo - comsol.it
Nerve injuries or breakage caused by bullet wounds or accidents often lead to loss of
sensitivity, or motion, or both, in the injured organ. The human body has inherent …