[HTML][HTML] Redox regulation of the immune response
G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
[HTML][HTML] Berberine: Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders
Berberine-containing plants have been traditionally used in different parts of the world for
the treatment of inflammatory disorders, skin diseases, wound healing, reducing fevers …
the treatment of inflammatory disorders, skin diseases, wound healing, reducing fevers …
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases
L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
[HTML][HTML] AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression
HC Xiang, LX Lin, XF Hu, H Zhu, HP Li… - Journal of …, 2019 - Springer
Background Chronic pain is a major clinical problem with limited treatment options. Previous
studies have demonstrated that activation of adenosine monophosphate-activated protein …
studies have demonstrated that activation of adenosine monophosphate-activated protein …
Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS
M Grégoire, F Uhel, M Lesouhaitier… - European …, 2018 - Eur Respiratory Soc
Exaggerated release of neutrophil extracellular traps (NETs) along with decreased NET
clearance and inability to remove apoptotic cells (efferocytosis) may contribute to sustained …
clearance and inability to remove apoptotic cells (efferocytosis) may contribute to sustained …
Metformin: experimental and clinical evidence for a potential role in emphysema treatment
F Polverino, TD Wu, J Rojas-Quintero… - American journal of …, 2021 - atsjournals.org
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation,
leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic …
leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic …
Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
A Salminen, K Kaarniranta, A Kauppinen - Ageing research reviews, 2016 - Elsevier
AMP-activated protein kinase (AMPK) is a fundamental regulator of energy metabolism,
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …
[HTML][HTML] Oximes: Novel therapeutics with anticancer and anti-inflammatory potential
IA Schepetkin, MB Plotnikov, AI Khlebnikov… - Biomolecules, 2021 - mdpi.com
Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …
GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis
Periodontitis is a chronic inflammatory disease caused by complex interactions between the
host immune system and pathogens that affect the integrity of periodontium. To prevent …
host immune system and pathogens that affect the integrity of periodontium. To prevent …
Nrf2 attenuates inflammatory response in COPD/emphysema: crosstalk with Wnt3a/β‐catenin and AMPK pathways
W Cui, Z Zhang, P Zhang, J Qu, C Zheng… - Journal of Cellular …, 2018 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow
limitation and abnormal inflammatory response. Wnt/β‐catenin and AMP‐activated protein …
limitation and abnormal inflammatory response. Wnt/β‐catenin and AMP‐activated protein …