The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Baroreflex Dysfunction Baroreflexes play both an adaptive and a homeostatic role,
maintaining blood pressure, heart rate, and blood volume within the normal range. Defects …

Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …

Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

Increased ventilation relative to metabolic demands, indicating alveolar hyperventilation
and/or increased physiological dead space (excess ventilation), is a key cause of exertional …

The motivation for this review comes from the emerging complexity of the autonomic
innervation of the carotid body (CB) and its putative role in regulating chemoreceptor …

The importance of chemoreflex function for cardiovascular health is increasingly recognized
in clinical practice. The physiological function of the chemoreflex is to constantly adjust …

Aims Increased chemosensitivity to carbon dioxide (CO2) is an important trigger of central
apnoeas (CA) in heart failure (HF), with negative impact on outcome. We hypothesized that …

Key points Although the exercise pressor reflex (EPR) and the chemoreflex (CR) are
recognized for their sympathoexcitatory effect, the cardiovascular implication of their …

Key points Heart failure with preserved ejection fraction (HFpEF) is associated with
disordered breathing patterns, and sympatho‐vagal imbalance. Although it is well accepted …