Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Pore-forming toxins in Cnidaria

M Podobnik, G Anderluh - Seminars in Cell & Developmental Biology, 2017 - Elsevier
The ancient phylum of Cnidaria contains many aquatic species with peculiar lifestyle. In
order to survive, these organisms have evolved attack and defense mechanisms that are …

Computational design of potent D-peptide inhibitors of SARS-CoV-2

PA Valiente, H Wen, S Nim, JA Lee… - Journal of medicinal …, 2021 - ACS Publications
Blocking the association between the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spike protein receptor-binding domain (RBD) and the human angiotensin …

Pore-forming proteins: From defense factors to endogenous executors of cell death

H Mesa-Galloso, L Pedrera, U Ros - Chemistry and physics of lipids, 2021 - Elsevier
Highlights•PFPs are fundamental defense and virulence factors in bacteria and as executors
of regulated cell death in eukaryotic cells.•Proteins and lipids cooperate to form different …

How a scorpion toxin selectively captures a prey sodium channel: the molecular and evolutionary basis uncovered

S Zhu, B Gao, S Peigneur, J Tytgat - Molecular biology and …, 2020 - academic.oup.com
The growing resistance of insects to chemical pesticides is reducing the effectiveness of
conventional methods for pest control and thus, the development of novel insecticidal agents …

Multigene Family of Pore-Forming Toxins from Sea Anemone Heteractis crispa

E Leychenko, M Isaeva, E Tkacheva, E Zelepuga… - Marine Drugs, 2018 - mdpi.com
Sea anemones produce pore-forming toxins, actinoporins, which are interesting as tools for
cytoplasmic membranes study, as well as being potential therapeutic agents for cancer …

Biophysical and biochemical strategies to understand membrane binding and pore formation by sticholysins, pore-forming proteins from a sea anemone

C Alvarez, U Ros, A Valle, L Pedrera, C Soto… - Biophysical …, 2017 - Springer
Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that
are able to bind and oligomerize in membranes, leading to cell swelling, impairment of ionic …

Membrane remodeling by the lytic fragment of SticholysinII: implications for the toroidal pore model

H Mesa-Galloso, PA Valiente, ME Valdés-Tresanco… - Biophysical journal, 2019 - cell.com
Sticholysins are pore-forming toxins of biomedical interest and represent a prototype of
proteins acting through the formation of protein-lipid or toroidal pores. Peptides spanning the …

Panorama of the intracellular molecular concert orchestrated by actinoporins, pore-forming toxins from sea anemones

C Alvarez, C Soto, S Cabezas, J Alvarado-Mesén… - Toxins, 2021 - mdpi.com
Actinoporins (APs) are soluble pore-forming proteins secreted by sea anemones that
experience conformational changes originating in pores in the membranes that can lead to …

The metamorphic transformation of a water-soluble monomeric protein into an oligomeric transmembrane pore

S García-Linares, E Rivera-de-Torre… - … in Biomembranes and …, 2017 - Elsevier
Sea anemones produce venoms containing different toxic molecules. Among them,
actinoporins are some of the best characterized ones. They constitute a family of toxic …