Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation
of immune and inflammatory responses and has been implicated in the pathogenesis of …

Myelination is an evolutionary recent differentiation program that has been independently
acquired in vertebrates by Schwann cells in the peripheral nervous system and …

The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases
through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic …

Many neurodegenerative diseases have been associated with defects in primary cilia, which
are cellular organelles involved in diverse cellular processes and homeostasis. Several …

Regeneration of damaged peripheral nerves remains one of the main challenges of
neurosurgery and regenerative medicine, a nerve functionality is rarely restored, especially …

Rationale: The peripheral nervous system (PNS) plays an important role in tumor growth
and progression. Schwann cells (SCs), the main glia cells of the PNS, augment cancer …