As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Ubiquitylation is one of the most abundant and versatile post-translational modifications
(PTMs) in cells. Its versatility arises from the ability of ubiquitin to form eight structurally and …

The proteasome has emerged as an intricate machine that has dynamic mechanisms to
regulate the timing of its activity, its selection of substrates, and its processivity. The 19 …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

The eukaryotic ubiquitin-proteasome system is responsible for most aspects of regulatory
and quality-control protein degradation in cells. Its substrates, which are usually modified by …

The 26S proteasome is involved in degrading and regulating the majority of proteins in
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …

The ubiquitin proteasome system (UPS) is the main ATP-dependent protein degradation
pathway in the cytosol and nucleus of eukaryotic cells. At its centre is the 26S proteasome …

INTRODUCTION The ubiquitin-proteasome system comprises hundreds of distinct pathways
of degradation, which converge at the step of ubiquitin recognition by the proteasome. Five …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …