Pharmacological safety evaluation of (pro) drugs includes cardiac safety assessment of
proarrhythmic liability in healthy tissue with emphasis on the rapid component of the delayed …

Proarrhythmic susceptibility to drug-induced Torsades de Pointes is restricted to individuals
with a predisposed phenotype characterized by a reduced repolarization reserve. Additional …

US 2012/0101539 A1 Apr. 26, 2012(Continued) Related US Application Data Primary
Examiner—Nicole F Lavert (60) Provisional application No. 61/139,094, filed on Dec.(74) …

Tools and methods are particularly suited for certain cardiac conditions involving use of a
catheter for pacing of the right and left ventricles from a lead in the right ventricle, eg, to …

Ventricular cardiac arrhythmia is a life threating condition arising from abnormal functioning
of many factors in concert. Animal models mirroring human electrophysiology are essential …

Background—Sustained bradycardia is associated with long-QT syndrome in human beings
and causes spontaneous torsades de pointes in rabbits with chronic atrioventricular block …

9, 1981 9, 1981 1, 1982 6, 1982 12, 1982 T. 1983 9, 1983 3, 1984 T. 1984 T. 1984 8, 1984
9, 1984 2, 1985 9, 1985 10, 1985 10, 1985 12, 1985 2, 1986 2, 1986 3, 1986 5, 1986 T …

Stimulation energy can be provided to a His-bundle to acti vate natural cardiac contraction
mechanisms. Interval infor mation can be used to describe a cardiac response to His bundle …

Tools and methods are particularly suited for certain cardiac conditions advantaged by
pacing of the right and left ventricles from a lead in the right ventricle, eg, to facilitate …

Disclosed are certain methods, apparatus, and processor readable mediums that may be
used to treat a conduction abnormality of the heart. In one example, the apparatus includes …