Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
KD Copps, MF White - Diabetologia, 2012 - Springer
The insulin receptor substrate proteins IRS1 and IRS2 are key targets of the insulin receptor
tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin …
tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin …
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
[HTML][HTML] Signalling by insulin and IGF receptors: supporting acts and new players
K Siddle - Journal of molecular endocrinology, 2011 - jme.bioscientifica.com
The signalling pathways utilised by insulin receptor (IR) and IGF receptor to transduce their
diverse effects on cellular metabolism, growth and survival are well established in broad …
diverse effects on cellular metabolism, growth and survival are well established in broad …
The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
X Zhang, Y Qiao, Q Wu, Y Chen, S Zou, X Liu… - Nature …, 2017 - nature.com
O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its
function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can …
function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can …
O-GlcNAc profiling: from proteins to proteomes
Abstract O-linked β-DN-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto
serine and threonine residues of proteins is an important post-translational modification …
serine and threonine residues of proteins is an important post-translational modification …
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression
YY Liu, HY Liu, TJ Yu, Q Lu, FL Zhang, GY Liu… - Cell Death & …, 2022 - nature.com
MORC family CW-type zinc finger 2 (MORC2) is a newly identified chromatin-remodeling
enzyme involved in DNA damage response and gene transcription, and its dysregulation …
enzyme involved in DNA damage response and gene transcription, and its dysregulation …
Targeting O-GlcNAcylation to develop novel therapeutics
Y Zhu, GW Hart - Molecular aspects of medicine, 2021 - Elsevier
O-linked β-DN-acetylglucosamine (O-GlcNAc) is an abundant post-translational modification
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
Akt/PKB: one kinase, many modifications
G Risso, M Blaustein, B Pozzi, P Mammi… - Biochemical …, 2015 - portlandpress.com
Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …