During the past decade, major advances have been made in the accurate diagnosis of
severe cutaneous adverse reactions (SCARs) to drugs, management of their manifestations …

Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient
pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Summary The International League Against Epilepsy has recently published a new
classification of epileptic seizures and epilepsies to reflect the major scientific advances in …

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening
mucocutaneous reactions, predominantly drug induced. The mortality rates for SJS and TEN …

CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …

The clinical manifestations of drug eruptions can range from mild maculopapular exanthema
to severe cutaneous adverse drug reactions (SCAR), including drug‐induced …

Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe
multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in …

Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …