AP-1 is a dimeric complex that is composed of JUN, FOS, ATF and MAF protein families.
FOS-related antigen 1 (FRA1) which encoded by FOSL1 gene, belongs to the FOS protein …

Oral squamous cell carcinoma (OSCC) is a common cancer characterised by low survival
rate and poor prognosis. The multistep process of oral carcinogenesis is affected by multiple …

Squamous cell carcinomas (SCCs) are highly heterogeneous tumours, resulting from
deranged expression of genes involved in squamous cell differentiation. Here we report that …

The transcription factor activator protein-1 (AP-1) has been implicated as a driver of
carcinogenesis since its original characterization. Oncogenic transcription factors like AP-1 …

The transcription factor AP1 (activating protein 1), a heterodimer of the JUN and FOS
proteins, promotes the invasive growth and metastasis of various tumors such as squamous …

The epidermis is a self-renewing tissue. The balance between proliferation and
differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) …

Introduction We previously reported that TRPM7 regulates glioma cells' stemness through
STAT3. In addition, we demonstrated that FOSL1 is a response gene for TRPM7, and the …

Fra-1 is overexpressed in a variety of human tumors. Whether MMP-9 expression is
regulated by Fra-1 has been contradictory. To clarify the capability of Fra-1 in activating …

Transcription factor activator protein‐1 (AP‐1) super‐family is known to modulate expression
of array of genes during development of many cancers and considered as an important …

Abstract FRA1 (Fos-like antigen 1) is highly expressed in many epithelial cancers including
squamous cell carcinoma of the skin (cSCC) and head and neck (HNSCC). However, the …