Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease
AC Müller-Nedebock, MCJ Dekker, MJ Farrer… - npj Parkinson's …, 2023 - nature.com
The biological basis of the neurodegenerative movement disorder, Parkinson's disease
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …
White matter injury across neurodegenerative disease
Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in shaping neuronal circuitry and function. It has become …
(CNS), are active players in shaping neuronal circuitry and function. It has become …
[HTML][HTML] Regional changes of brain structure during progression of idiopathic Parkinson's disease–A longitudinal study using deformation based morphometry
P Pieperhoff, M Südmeyer, L Dinkelbach, CJ Hartmann… - Cortex, 2022 - Elsevier
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum
of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD …
of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD …
[HTML][HTML] A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment
Ketones, the brain's alternative fuel to glucose, bypass the brain glucose deficit and improve
cognition in mild cognitive impairment (MCI). Our goal was to assess the impact of a 6-month …
cognition in mild cognitive impairment (MCI). Our goal was to assess the impact of a 6-month …
Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson's Disease
K Saramowicz, N Siwecka, G Galita… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a complex neurodegenerative disease characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …
Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression
Isolated REM sleep behaviour disorder (iRBD) is a synucleinopathy characterized by
abnormal behaviours and vocalizations during REM sleep. Most iRBD patients develop …
abnormal behaviours and vocalizations during REM sleep. Most iRBD patients develop …
Cortico–subcortical spatiotemporal dynamics in Parkinson's disease can be modulated by transcranial alternating current stimulation
T Liu, Z Yan, Z Han, J Zhang, B Fang… - Brain Science …, 2023 - journals.sagepub.com
Objective: We investigated changes in cortico–subcortical spatiotemporal dynamics to
explore the treatment mechanisms of transcranial alternating current stimulation (tACS) in …
explore the treatment mechanisms of transcranial alternating current stimulation (tACS) in …
Predicting longitudinal brain atrophy in Parkinson's disease using a Susceptible-Infected-Removed agent-based model
Parkinson's disease is a progressive neurodegenerative disorder characterized by
accumulation of abnormal isoforms of alpha-synuclein. Alpha-synuclein is proposed to act …
accumulation of abnormal isoforms of alpha-synuclein. Alpha-synuclein is proposed to act …
Neural correlates of obesity across the lifespan
Associations between brain and obesity are bidirectional: changes in brain structure and
function underpin over-eating, while chronic adiposity leads to brain atrophy. Investigating …
function underpin over-eating, while chronic adiposity leads to brain atrophy. Investigating …
Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies
Isolated rapid eye movement sleep behaviour disorder (iRBD) is a sleep disorder
characterized by the loss of rapid eye movement sleep muscle atonia and the appearance of …
characterized by the loss of rapid eye movement sleep muscle atonia and the appearance of …