Severe acute respiratory syndrome coronavirus 2 variants of concern: a perspective for emerging more transmissible and vaccine-resistant strains
AS de Souza, VM de Freitas Amorim, GDA Guardia… - Viruses, 2022 - mdpi.com
Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
(VOC) are constantly threatening global public health. With no end date, the pandemic …
(VOC) are constantly threatening global public health. With no end date, the pandemic …
Tracking the circulating SARS-CoV-2 variant of concern in South Africa using wastewater-based epidemiology
This study uses wastewater-based epidemiology (WBE) to rapidly and, through targeted
surveillance, track the geographical distribution of SARS-CoV-2 variants of concern (Alpha …
surveillance, track the geographical distribution of SARS-CoV-2 variants of concern (Alpha …
Evolution of SARS-CoV-2: BA. 4/BA. 5 variants continues to pose new challenges
The acquisition of a high number of mutations, notably, the gain of two mutations L452R and
F486V in RBD, and the ability to evade vaccine/natural infection-induced immunity suggests …
F486V in RBD, and the ability to evade vaccine/natural infection-induced immunity suggests …
Molecular dynamics simulations of the spike trimeric ectodomain of the SARS-CoV-2 Omicron variant: structural relationships with infectivity, evasion to immune …
AS de Souza, VMF Amorim, RF de Souza… - Journal of …, 2023 - Taylor & Francis
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron is currently
the most prevalent SARS-CoV-2 variant worldwide. Herein, we calculated molecular …
the most prevalent SARS-CoV-2 variant worldwide. Herein, we calculated molecular …
SARS-CoV-2 variants impact RBD conformational dynamics and ACE2 accessibility
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has killed over 6 million people and is having a devastating …
coronavirus 2 (SARS-CoV-2), has killed over 6 million people and is having a devastating …
Cooperative and structural relationships of the trimeric Spike with infectivity and antibody escape of the strains Delta (B. 1.617. 2) and Omicron (BA. 2, BA. 5, and BQ. 1 …
Herein, we conducted simulations of trimeric Spike from several SARS-CoV-2 variants of
concern (Delta and Omicron sub-variants BA. 2, BA. 5, and BQ. 1) and investigated the …
concern (Delta and Omicron sub-variants BA. 2, BA. 5, and BQ. 1) and investigated the …
Molecular Dynamics Simulations Suggest SARS-CoV-2 3CLpro Mutations in Beta and Omicron Variants Do Not Alter Binding Affinities for Cleavage Sites of Non …
VM de Freitas Amorim, RF de Souza, CR Guzzo… - COVID, 2023 - mdpi.com
In the course of SARS-CoV-2 infection, the 3CL or nsp5 protease plays a pivotal role as the
most important viral protease required for the maturation of viral proteins during host …
most important viral protease required for the maturation of viral proteins during host …
Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection
The first step of SARS-CoV-2 infection involves the interaction between the trimeric viral
spike protein (𝑆) and the host angiotensin-converting enzyme 2 (𝐴𝐶𝐸2). The receptor …
spike protein (𝑆) and the host angiotensin-converting enzyme 2 (𝐴𝐶𝐸2). The receptor …
Molecular dynamics simulations of the Spike trimeric ectodomain of the SARS-CoV-2 Omicron variant: structural relationships with infectivity, evasion to immune …
VMF Amorim, RF de Souza, AS Souza, CR Guzzo - bioRxiv, 2022 - biorxiv.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is
replacing Delta, the most prevalent variant worldwide from the beginning of 2021 until early …
replacing Delta, the most prevalent variant worldwide from the beginning of 2021 until early …
Cooperative and structural relationships of the trimeric Spike with infectivity and antibody escape of the strains Delta (B. 1.617. 2) and Omicron (BA. 2, BA. 5, and BQ. 1 …
Herein, we simulated the trimeric Spike of the variants B. 1.617. 2, BA. 2, BA. 5 and BQ. 1 for
300 ns. We derived mechanisms by which the substitutions K417N, L452R, N444T and …
300 ns. We derived mechanisms by which the substitutions K417N, L452R, N444T and …