The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—
the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome …

Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular
protective pathways may provide therapeutic targets for neurological disorders. S1P …

SARS-CoV-2 has been known remarkably since December 2019 as a strain of pathogenic
coronavirus. Starting from the earlier stages of the COVID-19 pandemic until now, we have …

Cerebral cavernous malformations (CCM) are lesions affecting brain capillaries that appear
with a mulberry-like morphology. This shape results from the enlarged and tangled …

The destruction of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) is
associated with poor prognosis. Modulation of sphingosine 1-phosphate receptor (S1PR) …

Fingolimod has generally shown neuroprotective effects in stroke models. Here, we tested
the hypothesis that fingolimod modulates T‐cell cytokine production towards a regulatory …

Background The blood‐brain barrier (BBB) plays a principal role in the healthy and
diseased central nervous systems, and BBB disruption after ischaemic stroke is responsible …

Endothelial integrity is critical in mitigating a vicious cascade of secondary injuries following
acute ischemic stroke (AIS). Matrix metalloproteinase-9 (MMP-9), a contributor to endothelial …

Finding novel and effective drugs for the treatment of ischemic stroke is warranted because
there is not a definitive treatment for this prevalent disease. Due to the relevance between …

Folic acid has a protective effect against ischemic stroke. However, the protective
pharmacological mechanism remains unclear. The aim of this study is to explore the …