The structures of type I polyketide synthases
AT Keatinge-Clay - Natural product reports, 2012 - pubs.rsc.org
Covering: up to 2012 With the recent structural characterization of each of the component
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …
Steps towards the synthetic biology of polyketide biosynthesis
M Cummings, R Breitling, E Takano - FEMS microbiology letters, 2014 - academic.oup.com
Nature is providing a bountiful pool of valuable secondary metabolites, many of which
possess therapeutic properties. However, the discovery of new bioactive secondary …
possess therapeutic properties. However, the discovery of new bioactive secondary …
Structure of a modular polyketide synthase
Polyketide natural products constitute a broad class of compounds with diverse structural
features and biological activities. Their biosynthetic machinery, represented by type I …
features and biological activities. Their biosynthetic machinery, represented by type I …
Engineering site-selective incorporation of fluorine into polyketides
S Sirirungruang, O Ad, TM Privalsky, S Ramesh… - Nature chemical …, 2022 - nature.com
Although natural products and synthetic small molecules both serve important medicinal
functions, their structures and chemical properties are relatively distinct. To expand the …
functions, their structures and chemical properties are relatively distinct. To expand the …
Structural rearrangements of a polyketide synthase module during its catalytic cycle
The polyketide synthase (PKS) mega-enzyme assembly line uses a modular architecture to
synthesize diverse and bioactive natural products that often constitute the core structures or …
synthesize diverse and bioactive natural products that often constitute the core structures or …
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways
Organofluorines represent a rapidly expanding proportion of molecules that are used in
pharmaceuticals, diagnostics, agrochemicals, and materials. Despite the prevalence of …
pharmaceuticals, diagnostics, agrochemicals, and materials. Despite the prevalence of …
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C …
Polyketide synthases (PKSs) represent a powerful catalytic platform capable of effecting
multiple carbon–carbon bond forming reactions and oxidation state adjustments. We …
multiple carbon–carbon bond forming reactions and oxidation state adjustments. We …
Uncovering the structures of modular polyketide synthases
KJ Weissman - Natural product reports, 2015 - pubs.rsc.org
Covering: up to 2014 The modular polyketide synthases (PKSs) are multienzyme proteins
responsible for the assembly of diverse secondary metabolites of high economic and …
responsible for the assembly of diverse secondary metabolites of high economic and …
Engineering polyketide synthases and nonribosomal peptide synthetases
GJ Williams - Current opinion in structural biology, 2013 - Elsevier
Highlights•We review engineering of polyketide synthases and nonribosomal peptide
synthetases.•Rational and evolutionary strategies for altering building block specificity are …
synthetases.•Rational and evolutionary strategies for altering building block specificity are …
Engineering the acyltransferase substrate specificity of assembly line polyketide synthases
Polyketide natural products act as a broad range of therapeutics, including antibiotics,
immunosuppressants and anti-cancer agents. This therapeutic diversity stems from the …
immunosuppressants and anti-cancer agents. This therapeutic diversity stems from the …