Cinnamic acid derivatives and their biological efficacy
N Ruwizhi, BA Aderibigbe - International journal of molecular sciences, 2020 - mdpi.com
The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes
and neurological disorders, among many, has been reported. Cinnamic acid is obtained …
and neurological disorders, among many, has been reported. Cinnamic acid is obtained …
Recent advances in the design and discovery of synthetic tyrosinase inhibitors
J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
The challenging melanoma landscape: From early drug discovery to clinical approval
M Matias, JO Pinho, MJ Penetra, G Campos, CP Reis… - Cells, 2021 - mdpi.com
Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …
resistance to currently used treatments. To overcome the limitations of the available …
Cinnamic acid derivatives linked to arylpiperazines as novel potent inhibitors of tyrosinase activity and melanin synthesis
R Romagnoli, P Oliva, F Prencipe, S Manfredini… - European Journal of …, 2022 - Elsevier
A novel series of twenty-seven cinnamides constituted by cinnamic acid derivatives liked to
1-aryl piperazines were synthesized and evaluated for their potential inhibitory diphenolase …
1-aryl piperazines were synthesized and evaluated for their potential inhibitory diphenolase …
Anti-tyrosinase and antimelanogenic effect of cinnamic acid derivatives from Prunus mahaleb L.: Phenolic composition, isolation, identification and inhibitory activity
Ethnopharmacological relevance The traditional use of Prunus species against skin
diseases and especially for skin lightning cosmeceutical purposes is widespread in many …
diseases and especially for skin lightning cosmeceutical purposes is widespread in many …
Molecular docking, synthesis, and tyrosinase inhibition activity of acetophenone amide: Potential inhibitor of melanogenesis
Tyrosinase and its related proteins are responsible for pigmentation disorders, and inhibiting
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …
Design, synthesis, and structural characterization of thioflavones and thioflavonols as potential tyrosinase inhibitors: In vitro and in silico studies
To find new potential tyrosinase inhibitors, a diverse range of 2-arylchromone-4-thione
derivatives (2a–2p) were designed and synthesized by employing a multistep strategy, and …
derivatives (2a–2p) were designed and synthesized by employing a multistep strategy, and …
Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters
J Li, X Min, X Zheng, S Wang, X Xu, J Peng - Molecules, 2023 - mdpi.com
Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its
inhibitors could be useful in preventing melanin-related diseases. To find potential …
inhibitors could be useful in preventing melanin-related diseases. To find potential …
Evaluation of 2,3-Dihydro-1,5-benzothiazepine Derivatives as Potential Tyrosinase Inhibitors: In Vitro and In Silico Studies
Benzothiazepines are pharmacologically active compounds, frequently utilized as a
precursor for acquiring versatile molecules with several bioactivities including anti …
precursor for acquiring versatile molecules with several bioactivities including anti …
Synthesis and biological evaluation of substituted aurone derivatives as potential tyrosinase inhibitors: in vitro, kinetic, QSAR, docking and drug-likeness studies
Tyrosinase enzyme plays an essential role in melanin biosynthesis and enzymatic browning
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …