Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

J MacAlpine, M Daniel-Ivad, Z Liu, J Yano… - Nature …, 2021 - nature.com
The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in
microbiome composition to invade its human host, causing pathologies ranging from vaginal …

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

C Fu, X Zhang, AO Veri, KR Iyer, E Lash, A Xue… - Nature …, 2021 - nature.com
Fungal pathogens pose a global threat to human health, with Candida albicans among the
leading killers. Systematic analysis of essential genes provides a powerful strategy to …

Molecular mechanisms governing antifungal drug resistance

Y Lee, N Robbins, LE Cowen - npj Antimicrobials and Resistance, 2023 - nature.com
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …

The role of Candida albicans stress response pathways in antifungal tolerance and resistance

KR Iyer, N Robbins, LE Cowen - Iscience, 2022 - cell.com
Human fungal pathogens are the causative agents of devastating diseases across the
globe, and the increasing prevalence of drug resistance threatens to undermine the already …

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

KR Iyer, K Camara, M Daniel-Ivad, R Trilles… - Nature …, 2020 - nature.com
Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs,
including the most commonly prescribed antifungal, fluconazole. Here, we use a …

New antifungal strategies: drug combination and co-delivery

P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …

Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity

KR Iyer, SC Li, NM Revie, JW Lou, D Duncan… - Cell chemical …, 2023 - cell.com
Rising drug resistance among pathogenic fungi, paired with a limited antifungal arsenal,
poses an increasing threat to human health. To identify antifungal compounds, we screened …

Advancements and challenges in antifungal therapeutic development

E Puumala, S Fallah, N Robbins… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Over recent decades, the global burden of fungal disease has expanded dramatically. It is
estimated that fungal disease kills approximately 1.5 million individuals annually; however …