Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …
globe. Candida species are among the most common causes of invasive mycotic disease …
Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …
along with significant agricultural crop loss caused by various fungal species, has resulted in …
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase
J MacAlpine, M Daniel-Ivad, Z Liu, J Yano… - Nature …, 2021 - nature.com
The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in
microbiome composition to invade its human host, causing pathologies ranging from vaginal …
microbiome composition to invade its human host, causing pathologies ranging from vaginal …
Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets
Fungal pathogens pose a global threat to human health, with Candida albicans among the
leading killers. Systematic analysis of essential genes provides a powerful strategy to …
leading killers. Systematic analysis of essential genes provides a powerful strategy to …
Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
The role of Candida albicans stress response pathways in antifungal tolerance and resistance
Human fungal pathogens are the causative agents of devastating diseases across the
globe, and the increasing prevalence of drug resistance threatens to undermine the already …
globe, and the increasing prevalence of drug resistance threatens to undermine the already …
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
KR Iyer, K Camara, M Daniel-Ivad, R Trilles… - Nature …, 2020 - nature.com
Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs,
including the most commonly prescribed antifungal, fluconazole. Here, we use a …
including the most commonly prescribed antifungal, fluconazole. Here, we use a …
New antifungal strategies: drug combination and co-delivery
P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …
resistance constitute a significant menace to human health. Antifungal drug combinations …
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity
Rising drug resistance among pathogenic fungi, paired with a limited antifungal arsenal,
poses an increasing threat to human health. To identify antifungal compounds, we screened …
poses an increasing threat to human health. To identify antifungal compounds, we screened …
Advancements and challenges in antifungal therapeutic development
Over recent decades, the global burden of fungal disease has expanded dramatically. It is
estimated that fungal disease kills approximately 1.5 million individuals annually; however …
estimated that fungal disease kills approximately 1.5 million individuals annually; however …