The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Experimental demonstration of highly reliable dynamic memristor for artificial neuron and neuromorphic computing

SO Park, H Jeong, J Park, J Bae, S Choi - Nature Communications, 2022 - nature.com
Neuromorphic computing, a computing paradigm inspired by the human brain, enables
energy-efficient and fast artificial neural networks. To process information, neuromorphic …

Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences

J Huang, Y Xu, Y Xue, Y Huang, X Li, X Chen… - Nature Biomedical …, 2023 - nature.com
Systematically identifying functional peptides is difficult owing to the vast combinatorial
space of peptide sequences. Here we report a machine-learning pipeline that mines the …

Peptide design principles for antimicrobial applications

MDT Torres, S Sothiselvam, TK Lu… - Journal of molecular …, 2019 - Elsevier
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

APD3: the antimicrobial peptide database as a tool for research and education

G Wang, X Li, Z Wang - Nucleic acids research, 2016 - academic.oup.com
The antimicrobial peptide database (APD, http://aps. unmc. edu/AP/) is an original database
initially online in 2003. The APD2 (2009 version) has been regularly updated and further …

cACP-DeepGram: classification of anticancer peptides via deep neural network and skip-gram-based word embedding model

S Akbar, M Hayat, M Tahir, S Khan, FK Alarfaj - Artificial intelligence in …, 2022 - Elsevier
Cancer is a Toxic health concern worldwide, it happens when cellular modifications cause
the irregular growth and division of human cells. Several traditional approaches such as …

Machine intelligence in peptide therapeutics: A next‐generation tool for rapid disease screening

S Basith, B Manavalan, T Hwan Shin… - Medicinal research …, 2020 - Wiley Online Library
Discovery and development of biopeptides are time‐consuming, laborious, and dependent
on various factors. Data‐driven computational methods, especially machine learning (ML) …

CancerPPD: a database of anticancer peptides and proteins

A Tyagi, A Tuknait, P Anand, S Gupta… - Nucleic acids …, 2015 - academic.oup.com
Abstract CancerPPD (http://crdd. osdd. net/raghava/cancerppd/) is a repository of
experimentally verified anticancer peptides (ACPs) and anticancer proteins. Data were …

Recurrent neural network model for constructive peptide design

AT Muller, JA Hiss, G Schneider - Journal of chemical information …, 2018 - ACS Publications
We present a generative long short-term memory (LSTM) recurrent neural network (RNN) for
combinatorial de novo peptide design. RNN models capture patterns in sequential data and …