Most organisms display endogenously produced∼ 24-hour fluctuations in physiology and
behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

For many individuals in industrialized nations, the widespread adoption of electric lighting
has dramatically affected the circadian organization of physiology and behavior. Although …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

Circadian rhythmicity in mammals is under the control of a molecular pacemaker constituted
of clock gene products organized in transcriptional autoregulatory loops. Phase resetting of …

With the exception of high latitudes, life has evolved under bright days and dark nights. Most
organisms have developed endogenously driven circadian rhythms that are synchronized to …

The goal of this review is to provide a perspective on the nature and importance of the
relationship between the circadian and pain systems. We provide: 1) An overview of the …

▪ Abstract The core apparatus that regulates circadian rhythm has been extensively studied
over the past five years. A looming question remains, however, regarding how this …

Light is a prominent stimulus that synchronizes endogenous circadian rhythmicity to
environmental light/dark cycles. Nocturnal light elevates mRNA of the Period1 (Per1) gene …

Light at night is a pervasive problem in our society; over 80% of the world's population
experiences significant light pollution. Exacerbating this issue is the reality that artificially lit …