Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …

Docetaxel (Taxotere®), a semi-synthetic analog of paclitaxel (Taxol®), is a promoter of
microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity …

PURPOSE: To develop a semimechanistic pharmacokinetic-pharmacodynamic model
describing chemotherapy-induced myelosuppression through drug-specific parameters and …

For about half a century, the binding of drugs to plasma albumin, the “silent receptor,” has
been recognized as one of the major determinants of drug action, distribution, and …

Docetaxel (Taxotere®) has been one of the most important chemotherapeutic drugs for
cancer treatment since 1996. Although a large number of clinical studies have been …

The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability,
gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus …

The anticancer drug docetaxel (Taxotere) is formulated in the nonionic surfactant
polysorbate 80 (Tween 80). Early in the clinical development of docetaxel, it became clear …

Albumin is a versatile drug carrier in anti-cancer drug delivery system and it also has an
actively targeting capacity to tumors. Recently, nanoparticle albumin-bound (nab™) …

The present invention relates to a pharmaceutical composition comprising a pharmaceutical
agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for …

Transfer of knowledge along the different phases of drug development is a fundamental
process in pharmaceutical research. In particular, cross-species extrapolation between …