Synthesis and Biological Studies of Benzo[b]furan Derivatives: A Review from 2011 to 2022

L Arce-Ramos, JC Castillo, D Becerra - Pharmaceuticals, 2023 - mdpi.com
The importance of the benzo [b] furan motif becomes evident in the remarkable results of
numerous biological investigations, establishing its potential as a robust therapeutic option …

Targeting bacterial sortases in search of anti-virulence therapies with low risk of resistance development

G Nitulescu, D Margina, A Zanfirescu, OT Olaru… - Pharmaceuticals, 2021 - mdpi.com
Increasingly ineffective antibiotics and rapid spread of multi-and pan-resistant bacteria
represent a global health threat; hence, the need of developing new antimicrobial …

Probing 2-acetylbenzofuran hydrazones and their metal complexes as α-glucosidase inhibitors

S Khan, M Tariq, M Ashraf, S Abdullah… - Bioorganic …, 2020 - Elsevier
Inhibition of α-glucosidase is one of the important approaches in designing antidiabetic
drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase …

An update on benzofuran inhibitors: a patent review

KM Dawood - Expert Opinion on Therapeutic Patents, 2019 - Taylor & Francis
Introduction: Benzofuran is a fundamental unit in numerous bioactive heterocycles. They
have attracted chemists and medical researchers due to their broad range of biological …

An efficient synthesis, structural (SC-XRD) and spectroscopic (FTIR, 1HNMR, MS spectroscopic) characterization of novel benzofuran-based hydrazones: An …

M Khalid, MN Arshad, MN Tahir, AM Asiri… - Journal of Molecular …, 2020 - Elsevier
Herein, the benzofuran-based hydrazones derivatives such as N'-(1-(benzofuran-2-yl)
ethylidene) isonicotinohydrazide (BEINH), N'-(1-(benzofuran-2-yl) ethylidene) nicotine …

Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative …

A Baldisserotto, M Demurtas, I Lampronti, D Moi… - European journal of …, 2018 - Elsevier
New benzofuranhydrazones 3–12 were easily prepared and assayed for their radical-
scavenging ability. Hydrazones 3–12 showed different extent antioxidant activity in DPPH …

The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment

JCJ Hintzen, H Abujubara, D Tietze… - … –A European Journal, 2024 - Wiley Online Library
This review covers the most recent advances in the development of inhibitors for the
bacterial enzyme sortase A (SrtA). Sortase A (SrtA) is a critical virulence factor, present …

Chemical biology of sortase a inhibition: A gateway to anti-infective therapeutic agents

R Sapra, AK Rajora, P Kumar, GP Maurya… - Journal of Medicinal …, 2021 - ACS Publications
Staphylococcus aureus is the leading cause of hospital-acquired infections. The enzyme
sortase A, present on the cell surface of S. aureus, plays a key role in bacterial virulence …

Design and Synthesis of Small Molecules as Potent Staphylococcus aureus Sortase A Inhibitors

MW Ha, SW Yi, SM Paek - Antibiotics, 2020 - mdpi.com
The widespread and uncontrollable emergence of antibiotic-resistant bacteria, especially
methicillin-resistant Staphylococcus aureus, has promoted a wave of efforts to discover a …

Discovery of Sortase A covalent inhibitors with benzofuranene cyanide structures as potential antibacterial agents against Staphylococcus aureus

S Lei, Y Hu, C Yuan, R Sun, J Wang, Y Zhang… - European Journal of …, 2022 - Elsevier
Sortase A (SrtA) is a cysteine transpeptidase of most gram-positive bacteria that is
responsible for the anchoring of many surface protein virulence factors to the cell wall. SrtA …