Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …

The blood-brain barrier (BBB) is a unique set of properties of the brain vasculature which
severely restrict its permeability to proteins and small molecules. Classic chick-quail chimera …

Astrocytes, often considered as secondary responders to neurodegeneration, are emerging
as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in …

Hypothalamic astrocytes are particularly affected by energy‐dense food consumption. How
the anatomical location of these glial cells and their spatial molecular distribution in the …

Neuronal heterogeneity has been established as a pillar of higher central nervous system
function, but glial heterogeneity and its implications for neural circuit function are poorly …

Cellular identity is established through complex layers of genetic regulation, forged over a
developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these …

Adult stem cells are important for tissue turnover and regeneration. However, in most adult
systems it remains elusive how stem cells assume different functional states and support …

Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make‐up
and cell biology, which results in changes in astrocyte function. These changes can be …