Pathophysiology and therapy of experimental stroke

KA Hossmann - Cellular and molecular neurobiology, 2006 - Springer
1. Stroke is the neurological evidence of a critical reduction of cerebral blood flow in a
circumscribed part of the brain, resulting from the sudden or gradually progressing …

The role of aquaporin 4 in the brain

C Iacovetta, E Rudloff, R Kirby - Veterinary Clinical Pathology, 2012 - Wiley Online Library
Emerging evidence suggests that aquaporin (AQP) 4 water channels play an important role
in water homeostasis in the brain. These water channels are most abundant in the cell …

The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury

T Higashida, CW Kreipke, JA Rafols, C Peng… - Journal of …, 2011 - thejns.org
Object The present study investigated the role of hypoxia-inducible factor-1α (HIF-1α),
aquaporin-4 (AQP-4), and matrix metalloproteinase-9 (MMP-9) in blood-brain barrier (BBB) …

Characteristic brain magnetic resonance imaging abnormalities in central nervous system aquaporin-4 autoimmunity

W Kim, MS Park, SH Lee, SH Kim… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Background: Although neuromyelitis optica has been traditionally regarded as a disease
without brain involvement, brain abnormalities are not uncommon in patients with …

Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats

Q Guo, I Sayeed, LM Baronne, SW Hoffman… - Experimental …, 2006 - Elsevier
This study investigates whether progesterone administration regulates AQP4 and GFAP
expression in rats with bilateral contusion injuries of the medial frontal cortex. Male rats were …

Evaluation of inner retinal layers in patients with multiple sclerosis or neuromyelitis optica using optical coherence tomography

DB Fernandes, AS Raza, RGF Nogueira, D Wang… - Ophthalmology, 2013 - Elsevier
PURPOSE: To evaluate the thickness of the inner retinal layers in the macula using
frequency-domain optical coherence tomography (fd-OCT) in patients with demyelinating …

Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury

G Esposito, J Imitola, J Lu, D De Filippis… - Human molecular …, 2008 - academic.oup.com
Down syndrome (DS) is caused by trisomy of chromosome 21 and is characterized by
mental retardation, seizures and premature Alzheimer's disease. To examine …

Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood–brain barrier disruption and brain edema after …

Z Wang, CJ Meng, XM Shen, Z Shu, C Ma… - Journal of molecular …, 2012 - Springer
The current research aimed to investigate the role of hypoxia-inducible factor-1α (HIF-1α),
aquaporin-4 (AQP-4), and matrix metalloproteinase-9 (MMP-9) in blood–brain barrier (BBB) …

Hypoxia-inducible factor-1α signaling in aquaporin upregulation after traumatic brain injury

JY Ding, CW Kreipke, SL Speirs, P Schafer… - Neuroscience …, 2009 - Elsevier
Previous studies have demonstrated that traumatic brain injury (TBI) causes brain edema via
aquaporins (AQPs), the water-transporting proteins. In the present study, we determined the …

Role of aquaporins in the physiological functions of mesenchymal stem cells

A Zannetti, G Benga, A Brunetti, F Napolitano… - Cells, 2020 - mdpi.com
Aquaporins (AQPs) are a family of membrane water channel proteins that control osmotically-
driven water transport across cell membranes. Recent studies have focused on the …