The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

THE autosomal recessive mouse mutation reeler 1–3 leads to impaired motor coordination,
tremors and ataxia4. Neurons in affected mice fail to reach their correct locations in the …

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in
the proper functioning of articular cartilage because it provides a hydrated gel structure (via …

Proteoglycans are widely expressed in animal cells. Interactions between negatively
charged glycosaminoglycan chains and molecules such as growth factors are essential for …

We describe the primary structure of rat betaglycan, a polymorphic membrane-anchored
proteoglycan with high affinity for transformlng growth factor-p (TGF-p). As deduced from its …

Aggrecan, a large aggregating proteoglycan, is one of the major structural components of
cartilage. Its core protein contains three glubular domains and two …

Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored
proteoglycan that presents TGF-beta to the type II signaling receptor, a transmembrane …

The primary structure of a large chondroitin sulfate proteoglycan expressed by human
fibroblasts has been determined. Overlapping cDNA clones code for the entire 2389 amino …

During feeding by infected mosquitoes, malaria sporozoites are injected into the host's
bloodstream and enter hepatocytes within minutes. The remarkable target cell specificity of …