Context.—There have been major advances in the understanding of melanoma since the
last revision of the World Health Organization (WHO) classification in 2006. Objective.—To …

PRAME is a novel immunohistochemical marker that aids the diagnosis of melanocytic
lesions. Diffuse PRAME positivity suggests melanoma, whereas benign naevi are negative …

Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data
show the involvement of senescent cells in tissue ageing and some age-related diseases …

Context.—Making an accurate diagnosis for melanocytic lesions has always been
challenging for pathologists, especially when dealing with difficult-to-diagnose cases …

Cutaneous melanoma (CM) is known as an aggressive malignant cancer; some of which are
directly derived from melanocytic nevi, which have been attracting growing attention from the …

Cancer treatment often tends to involve direct targeting enzymes essential for the growth
and proliferation of cancer cells. The aim of this study was the recognition of the possible …

Melanoma is the most lethal skin cancer with increasing incidence worldwide. Despite a
great improvement of diagnostics and treatment of melanoma patients, this disease is still a …

Background Skin cutaneous melanoma (SKCM) accounts for over 75% of skin cancer-
related deaths each year. EAF2, as a member of EAF family, has been found in several …

Aim: To analyze BRAF V600E, p16 expression and melanocyte proliferation in dermal,
compound and dysplastic nevi, cells of primary and metastatic melanoma in the Polish …

Background Accurate classification of spitzoid melanocytic lesions is difficult due to
overlapping clinical and histopathologic features between Spitz nevi, atypical Spitz tumors …