Compelling data supports the hypothesis that Pin1 inhibitors will be useful for the therapy of
cancer: Pin1 deficient mice resist the induction of breast cancers normally evoked by …

Estrogen receptor alpha (ER) is a transcriptional regulator that controls the expression of
genes related to cellular proliferation and differentiation in normal mammary tissue …

Parvulins belong to the family of peptidyl-prolyl cis/trans isomerases (PPIases) assisting in
protein folding and in regulating the function of a broad variety of proteins in all branches of …

Pin1 regulates the levels and functions of phosphoproteins by catalyzing phosphorylation-
dependent cis/trans isomerization of peptidyl–prolyl bonds. Previous Pin1 inhibitors …

The design of potent Pin1 inhibitors has been challenging because its active site specifically
recognizes a phospho-protein epitope. The de novo design of phosphate-based Pin1 …

Pin1 (proline isomerase peptidyl-prolyl isomerase NIMA-interacting-1), as a member of
PPIase family, catalyzes cis–trans isomerization of pThr/Ser-Pro amide bonds of its substrate …

Estrogen receptor alpha (ERα) is detected in more than 70% of the cases of breast cancer.
Nuclear activity of ERα, a transcriptional regulator, is linked to the development of mammary …

Cell cycle regulatory enzyme Pin1 both catalyzes pSer/Thr-cis/trans-Pro isomerization and
binds the same motif separately in its WW domain. To better understand the function of Pin1 …

The mitotic regulator Pin1 plays an important role in protein quality control and age-related
medical conditions such as Alzheimer disease and Parkinson disease. Although its cellular …

In this work, a series of novel benzimidazole derivatives were designed and synthesized as
Pin1 inhibitors. Protease-coupled assay was used to investigate the Pin1 inhibitory potency …