Background Psychological treatments occupy an important place in evidence-based mental
health treatments. Now is an exciting time to fuel treatment research: a pressing demand for …

The reactivation of a stored memory in the brain can make the memory transiently labile.
During the time it takes for the memory to restabilize (reconsolidate) the memory can either …

Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules
(MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent …

A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …

Since Freud, clinicians have understood that disturbing memories contribute to
psychopathology and that new emotional experiences contribute to therapeutic change. Yet …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Memory of a traumatic event becomes consolidated within hours. Intrusive memories can
then flash back repeatedly into the mind's eye and cause distress. We investigated whether …

The acquisition of fear associative memory requires brain processes of coordinated neural
activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem …

The effects of propranolol in the treatment of anxiety disorders have not been systematically
evaluated previously. The aim was to conduct a systematic review and meta-analysis of …