Recent advances in analytical techniques have opened new opportunities for plant-based
drug discovery in the field of peptide and proteins. Enzymatic hydrolysis of plant parent …

The multivariable and progressive natural history of type 2 diabetes limits the effectiveness
of available glucose-lowering drugs. Constraints imposed by comorbidities (notably …

The dried fruits of Amomum tsao-ko were first revealed to have hypoglycemic effects on
db/db mice at a concentration of 200 mg/kg. In order to clarify the antidiabetic constituents …

Introduction or background Type 2 diabetes, which accounts for~ 90% of all diabetes, is a
heterogeneous and progressive disease with a variety of causative and potentiating factors …

Insulin resistance (IR) plays an important role in the pathogenesis of type 2 diabetes (T2D)
and cardiovascular disease. Hence improving IR is a major target of treatment in patients …

Protein tyrosine phosphatase 1B (PTP1B) has already been well studied as a highly
validated therapeutic target for diabetes and obesity. However, the lack of selectivity limited …

During an effort to find insulin mimetic compounds, the leaves of Gymnema inodorum were
shown to have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. Bioassay …

This study investigated the effects of local delivery of manganese chloride (MnCl2), an
insulin‐mimetic compound, upon fracture healing using a rat femoral fracture model …

Protein tyrosine phosphatase 1B (PTP1B) has been considered as a validated biological
target for type 2 diabetes treatment, but past endeavors to develop inhibitors of PTP1B into …

Control of postprandial hyperglycemia is crucial in the management of diabetes mellitus.
Despite the use of the current hypoglycemic drugs, incidence of diabetes and related …