[HTML][HTML] PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

MC Operti, A Bernhardt, S Grimm, A Engel… - International Journal of …, 2021 - Elsevier
Nanomedicines based on poly (lactic-co-glycolic acid)(PLGA) carriers offer tremendous
opportunities for biomedical research. Although several PLGA-based systems have already …

Polymeric nanoparticles: A study on the preparation variables and characterization methods

CIC Crucho, MT Barros - Materials Science and Engineering: C, 2017 - Elsevier
Since the emergence of Nanotechnology in the past decades, the development and design
of nanomaterials has become an important field of research. An emerging component in this …

Exosome detection via the ultrafast-isolation system: EXODUS

Y Chen, Q Zhu, L Cheng, Y Wang, M Li, Q Yang, L Hu… - Nature …, 2021 - nature.com
Exosomes have shown great potential in disease diagnostics and therapeutics. However,
current isolation approaches are burdensome and suffer from low speed, yield and purity …

Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

A Mandal, R Bisht, ID Rupenthal, AK Mitra - Journal of Controlled Release, 2017 - Elsevier
Effective intraocular drug delivery poses a major challenge due to the presence of various
elimination mechanisms and physiological barriers that result in low ocular bioavailability …

Methods for the preparation and manufacture of polymeric nanoparticles

C Vauthier, K Bouchemal - Pharmaceutical research, 2009 - Springer
This review summarizes the different methods of preparation of polymer nanoparticles
including nanospheres and nanocapsules. The first part summarizes the basic principle of …

Toward greener nanosynthesis

JA Dahl, BLS Maddux, JE Hutchison - Chemical reviews, 2007 - ACS Publications
During the past decade, scientists have developed techniques for synthesizing and
characterizing many new materials with at least one dimension on the nanoscale, including …

Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx

TD Naquin, AJ Canning, Y Gu, J Chen, CM Naquin… - Science …, 2024 - science.org
Efficient isolation and analysis of exosomal biomarkers hold transformative potential in
biomedical applications. However, current methods are prone to contamination and require …

Recent advances in polymeric nanoparticle-encapsulated drugs against intracellular infections

A Sánchez, SP Mejía, J Orozco - Molecules, 2020 - mdpi.com
Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat
intracellular infections. They have outstanding performance in delivering antimicrobials …

Chitosans for delivery of nucleic acids

MD Buschmann, A Merzouki, M Lavertu… - Advanced drug delivery …, 2013 - Elsevier
Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety
profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …

Purification processes of polymeric nanoparticles: How to improve their clinical translation?

SF Tehrani, P Bharadwaj, JL Chain… - Journal of Controlled …, 2023 - Elsevier
Polymeric nanoparticles, as revolutionary nanomedicines, have offered a new class of
diagnostic and therapeutic solutions for a multitude of diseases. With its immense potential …