Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Who is more contemptible than he who scorns knowledge of himself?—John of Salisbury
bodies; and the autoreactive T cell dependence of IDDM pathogenesis and the ability to …

Summary Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function
activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and …

Adaptive features of innate immunity, also termed 'trained immunity', have recently been
shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity …

Ethical considerations constrain the in vivo study of human hemopoietic stem cells (HSC).
To overcome this limitation, small animal models of human HSC engraftment have been …

Dextran sulfate sodium (DSS)-induced murine colitis represents an experimental model for
human inflammatory bowel disease. The aim of this study was to screen various inbred …

The discovery of the severe combined immunodeficiency (scid) mouse mutation has
provided a tool for establishment of small animal models as hosts for the in vivo analysis of …

This immunohistochemical study describes the infiltration pattern of monocytes-
macrophages and dendritic cells during the development of insulitis and diabetes in the …

Specific allelic combinations within the class II region of the major histocompatibility complex
(MHC) represent a major genetic component for susceptibility to autoimmune insulin …

Abstract Aims/hypothesis 1, 25-dihydroxyvitamin D 3, the active form of vitamin D, prevents
Type 1 diabetes in non-obese diabetic (NOD) mice. Epidemiological data show a threefold …