A global analysis of function and conservation of catalytic residues in enzymes
AJM Ribeiro, JD Tyzack, N Borkakoti… - Journal of Biological …, 2020 - ASBMB
The catalytic residues of an enzyme comprise the amino acids located in the active center
responsible for accelerating the enzyme-catalyzed reaction. These residues lower the …
responsible for accelerating the enzyme-catalyzed reaction. These residues lower the …
RCSB Protein Data Bank (RCSB. org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from …
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …
Enzymes from extreme environments and their industrial applications
JA Littlechild - Frontiers in bioengineering and biotechnology, 2015 - frontiersin.org
This article will discuss the importance of specific extremophilic enzymes for applications in
industrial biotechnology. It will specifically address those enzymes that have applications in …
industrial biotechnology. It will specifically address those enzymes that have applications in …
High-resolution de novo structure prediction from primary sequence
Recent breakthroughs have used deep learning to exploit evolutionary information in
multiple sequence alignments (MSAs) to accurately predict protein structures. However …
multiple sequence alignments (MSAs) to accurately predict protein structures. However …
ProteinBERT: a universal deep-learning model of protein sequence and function
Self-supervised deep language modeling has shown unprecedented success across natural
language tasks, and has recently been repurposed to biological sequences. However …
language tasks, and has recently been repurposed to biological sequences. However …
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental …
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), the US data center for the global PDB archive and a founding member of the …
PDB), the US data center for the global PDB archive and a founding member of the …
[HTML][HTML] Expansion of the global RNA virome reveals diverse clades of bacteriophages
High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …
PDBsum: Structural summaries of PDB entries
PDBsum is a web server providing structural information on the entries in the Protein Data
Bank (PDB). The analyses are primarily image‐based and include protein secondary …
Bank (PDB). The analyses are primarily image‐based and include protein secondary …
The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures
A Andreeva, E Kulesha, J Gough… - Nucleic acids …, 2020 - academic.oup.com
Abstract The Structural Classification of Proteins (SCOP) database is a classification of
protein domains organised according to their evolutionary and structural relationships. We …
protein domains organised according to their evolutionary and structural relationships. We …
Molecular architecture of the human caveolin-1 complex
Membrane-sculpting proteins shape the morphology of cell membranes and facilitate
remodeling in response to physiological and environmental cues. Complexes of the …
remodeling in response to physiological and environmental cues. Complexes of the …