Novel 1, 2, 4‐Triazoles as Antifungal Agents

Z Kazeminejad, M Marzi, A Shiroudi… - BioMed Research …, 2022 - Wiley Online Library
The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …

An insight into the recent developments in anti-infective potential of indole and associated hybrids

BS Mathada, SB Somappa - Journal of Molecular Structure, 2022 - Elsevier
Prevention, accurate diagnosis, and effective treatment of infections are the main challenges
in the overall management of infectious diseases. The best example is the ongoing SARs …

Indole clubbed 2, 4‐thiazolidinedione linked 1, 2, 3‐triazole as a potent antimalarial and antibacterial agent against drug‐resistant strain and molecular modeling …

DB Upadhyay, JA Mokariya, PJ Patel… - Archiv der …, 2024 - Wiley Online Library
In the face of escalating challenges of microbial resistance strains, this study describes the
design and synthesis of 5‐({1‐[(1H‐1, 2, 3‐triazol‐4‐yl) methyl]‐1H‐indol‐3‐yl} methylene) …

Isatin conjugates as antibacterial agents: a brief review

F Hassan, I Azad, M Asif, D Shukla… - Medicinal …, 2023 - ingentaconnect.com
Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …

[HTML][HTML] Computational analysis of substituent effect on indole derivatives as potential antibacterial agents

S Bince, SS Dindorkar, A Yadav - Chemical Physics Impact, 2022 - Elsevier
In recent years, indole derivatives have gained attention as an important class of
antimicrobial drugs. The modification of 1, 3, 4-oxadiazole and 1, 2, 4-triazole, which are …

A review of the therapeutic importance of indole scaffold in drug discovery

N Teraiya, K Agrawal, TM Patel, A Patel… - Current Drug …, 2023 - ingentaconnect.com
Indole is known as a versatile heterocyclic building block for its multiple pharmacological
activities and has a high probability of success in the race for drug candidates. Many natural …

Synthesis of novel indole Schiff base compounds and their antifungal activities

C Wang, L Fan, Z Pan, S Fan, L Shi, X Li, J Zhao, L Wu… - Molecules, 2022 - mdpi.com
A series of novel indole Schiff base derivatives (2a–2t) containing a 1, 3, 4-thiadiazole
scaffold modified with a thioether group were synthesized, and their structures were …

Searching for Conjugates as New Structures for Antifungal Therapies

I Muszalska-Kolos, PM Dwiecki - Journal of Medicinal Chemistry, 2024 - ACS Publications
The progressive increase in fungal infections and the decrease in the effectiveness of
current therapy explain research on new drugs. The synthesis of compounds with proven …

Phytochemical-mediated regulation of aflatoxigenic fungi contamination in a shifting climate and environment

S Zaman, N Khan, M Zahoor, R Ullah, A Bari… - … Geochemistry and Health, 2024 - Springer
Mycotoxin contamination poses a significant problem in developing countries, particularly in
northern Pakistan's fluctuating climate. This study aimed to assess aflatoxin contamination in …

N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation

A Petrou, A Geronikaki, V Kartsev, A Kousaxidis… - Pharmaceuticals, 2023 - mdpi.com
Herein, we report the experimental evaluation of the antimicrobial activity of seventeen new
(Z)-methyl 3-(4-oxo-2-thioxothiazolidin-5-ylidene) methyl)-1 H-indole-2-carboxylate …