[HTML][HTML] Regulation of breathing and autonomic outflows by chemoreceptors
PG Guyenet - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control
PG Guyenet, RL Stornetta… - Journal of applied …, 2010 - journals.physiology.org
In this review, we examine why blood pressure (BP) and sympathetic nerve activity (SNA)
increase during a rise in central nervous system (CNS) Pco2 (central chemoreceptor …
increase during a rise in central nervous system (CNS) Pco2 (central chemoreceptor …
A genetically defined circuit for arousal from sleep during hypercapnia
The precise neural circuitry that mediates arousal during sleep apnea is not known. We
previously found that glutamatergic neurons in the external lateral parabrachial nucleus …
previously found that glutamatergic neurons in the external lateral parabrachial nucleus …
Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men
Key points Central chemoreceptor stimulation, by hypercapnia (acidosis), and peripheral, by
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …
Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats
SBG Abbott, RL Stornetta, MB Coates… - Journal of …, 2011 - Soc Neuroscience
The retrotrapezoid nucleus contains Phox2b-expressing glutamatergic neurons (RTN-
Phox2b neurons) that regulate breathing in a CO2-dependent manner. Here we use …
Phox2b neurons) that regulate breathing in a CO2-dependent manner. Here we use …
Selective optogenetic activation of rostral ventrolateral medullary catecholaminergic neurons produces cardiorespiratory stimulation in conscious mice
SBG Abbott, SD DePuy, T Nguyen… - Journal of …, 2013 - Soc Neuroscience
Activation of rostral ventrolateral medullary catecholaminergic (RVLM-CA) neurons eg, by
hypoxia is thought to increase sympathetic outflow thereby raising blood pressure (BP) …
hypoxia is thought to increase sympathetic outflow thereby raising blood pressure (BP) …
Multi-level regulation of opioid-induced respiratory depression
B Palkovic, V Marchenko, EJ Zuperku… - …, 2020 - journals.physiology.org
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from
direct effects on the preBötzinger Complex as well as from depression of the …
direct effects on the preBötzinger Complex as well as from depression of the …
Optogenetic stimulation of adrenergic C1 neurons causes sleep state–dependent cardiorespiratory stimulation and arousal with sighs in rats
Rationale: The rostral ventrolateral medulla (RVLM) contains central respiratory
chemoreceptors (retrotrapezoid nucleus, RTN) and the sympathoexcitatory, hypoxia …
chemoreceptors (retrotrapezoid nucleus, RTN) and the sympathoexcitatory, hypoxia …
Central nervous system distribution of the transcription factor Phox2b in the adult rat
BJ Kang, DA Chang, DD Mackay… - Journal of …, 2007 - Wiley Online Library
Phox2b is required for development of the peripheral autonomic nervous system and a
subset of cranial nerves and lower brainstem nuclei. Phox2b mutations in man cause diffuse …
subset of cranial nerves and lower brainstem nuclei. Phox2b mutations in man cause diffuse …
Selective lesion of retrotrapezoid Phox2b‐expressing neurons raises the apnoeic threshold in rats
AC Takakura, TS Moreira, RL Stornetta… - The Journal of …, 2008 - Wiley Online Library
Injection of the neurotoxin saporin–substance P (SSP‐SAP) into the retrotrapezoid nucleus
(RTN) attenuates the central chemoreflex in rats. Here we ask whether these deficits are …
(RTN) attenuates the central chemoreflex in rats. Here we ask whether these deficits are …