[HTML][HTML] The role of HSP90 inhibitors in the treatment of cardiovascular diseases

S Qi, G Yi, K Yu, C Feng, S Deng - Cells, 2022 - mdpi.com
Cardiovascular disease is the result of complicated pathophysiological processes in the
tissues that make up the blood vessels and heart. Heat shock protein 90 (HSP90) can …

[HTML][HTML] Atheroprotective aspects of heat shock proteins

AV Poznyak, VA Orekhova, VN Sukhorukov… - International journal of …, 2023 - mdpi.com
Atherosclerosis is a major global health problem. Being a harbinger of a large number of
cardiovascular diseases, it ultimately leads to morbidity and mortality. At the same time …

[HTML][HTML] Exploring potential biomarkers and molecular mechanisms of ischemic cardiomyopathy and COVID-19 comorbidity based on bioinformatics and systems …

S Luo, X Zhang, X Xiao, W Luo, Z Yang, S Tang… - International Journal of …, 2023 - mdpi.com
Cardiovascular complications combined with COVID-19 (SARS-CoV-2) lead to a poor
prognosis in patients. The common pathogenesis of ischemic cardiomyopathy (ICM) and …

[HTML][HTML] Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Y Zou, H Shi, N Liu, H Wang, X Song… - Frontiers in …, 2023 - frontiersin.org
Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a
variety of cellular stress states. It is involved in regulating proteostasis and protecting cells …

[HTML][HTML] Proteome analysis, bioinformatic prediction and experimental evidence revealed immune response down-regulation function for serum-starved human …

N Jafari, R Gheitasi, HR Khorasani, M Golpour… - Heliyon, 2023 - cell.com
Emerging evidence indicates that fibroblasts play pivotal roles in immunoregulation by
producing various proteins under health and disease states. In the present study, for the first …

[HTML][HTML] Selenium Nanoparticles Can Influence the Immune Response Due to Interactions with Antibodies and Modulation of the Physiological State of Granulocytes

VV Khabatova, DA Serov, IV Tikhonova, ME Astashev… - Pharmaceutics, 2022 - mdpi.com
Currently, selenium nanoparticles (SeNPs) are considered potential immunomodulatory
agents and as targets for activity modulation are granulocytes, which have the most …

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

Z Liu, X Bian, L Li, L Liu, C Feng, Y Wang… - Advanced …, 2024 - Wiley Online Library
Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the
underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific …

Human Plasma‐Derived Extracellular Vesicles Protect Against Cerebral Ischemia‐Reperfusion Injury via HSP27 Phosphorylation

Y Wang, H Yang, L Zhao, X Yin, S Ai, M Hu… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke (IS) has become a serious public health problem, with patients undergoing
endovascular treatment experiencing ischemia‐reperfusion (I/R) injury, which exacerbates …

[HTML][HTML] Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila

Y Li, Z Jiang, Y Xu, J Yan, Q Wu, S Huang… - International Journal of …, 2024 - mdpi.com
Pygopus (Pygo) has been identified as a specific nuclear co-activator of the canonical
Wingless (Wg)/Wnt signaling pathway in Drosophila melanogaster. Pygo proteins consist of …

[HTML][HTML] Study of the Effects of Selenium Nanoparticles and Their Combination with Immunoglobulins on the Survival and Functional State of Polymorphonuclear Cells

DA Serov, VV Khabatova, IV Tikhonova… - Opera medica et …, 2022 - cyberleninka.ru
Selenium and its compounds are promising immunomodulatory agents. We studied the
ability of selenium nanoparticles (Se NPs) and their combination with immunoglobulins (IgG) …