This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Primary cancer cell lines are ex vivo cell cultures originating from resected tissues during
biopsies and surgeries. Primary cell cultures are objects of intense research due to their …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …

Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …

The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …

In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate
damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian …

Objective Glucagon is well known to regulate blood glucose but may be equally important
for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon …

Animal testing is still the most popular preclinical assessment model for liver fibrosis. To
develop efficient anti-fibrotic therapies, robust and representative in vitro models are …

Abstract Background Hepatitis B virus (HBV) is the leading cause of liver cancer, but the
mechanisms by which HBV causes liver cancer are poorly understood and …