Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …

Circular RNAs open a new chapter in cardiovascular biology

S Aufiero, YJ Reckman, YM Pinto… - Nature Reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This
unusual class of RNA species is generated by a back-splicing event of one or two exons …

[HTML][HTML] The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

J Wang, Y Zhang, H Song, H Yin, T Jiang, Y Xu, L Liu… - Molecular cancer, 2021 - Springer
Abstract Background Noncoding RNAs such as circular RNAs (circRNAs) are abundant in
the human body and influence the occurrence and development of various diseases …

[HTML][HTML] Circular RNA: an important player with multiple facets to regulate its parental gene expression

T Shao, Y Pan, X Xiong - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Circular RNAs (circRNAs), a novel type of endogenous RNAs with covalently closed-loop
structures, have become a new research hotspot in the RNA world. Their diversity, stability …

Circular RNAs: the star molecules in cancer

J Liu, D Li, H Luo, X Zhu - Molecular aspects of medicine, 2019 - Elsevier
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a closed loop
structure. These RNAs are produced by pre-mRNA through variable shear processing and …

[HTML][HTML] Circular RNAs: a novel class of functional RNA molecules with a therapeutic perspective

L Santer, C Bär, T Thum - Molecular Therapy, 2019 - cell.com
Circular RNAs (circRNAs) are a subclass of non-coding RNAs that lack free 3′ and 5′
ends and, thus, exist as continuous loop RNAs. Such circular transcripts have been …

Intriguing circles: conflicts and controversies in circular RNA research

HM Li, XL Ma, HG Li - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Circular RNAs (circRNAs) are covalently closed RNA circles without a 5′ cap or 3′ tail.
Since the landmark discovery of ciRS‐7/CDR1as functioning as a miR‐7 sponge in 2013 …

Circular RNA involvement in aging: an emerging player with great potential

H Cai, Y Li, JD Niringiyumukiza, P Su… - Mechanisms of ageing and …, 2019 - Elsevier
Circular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting
as a special covalent loop without a 5′ cap or 3′ tail. Multiple biological properties of …

[HTML][HTML] N6-methyladenosine modification opens a new chapter in circular RNA biology

J Wu, X Guo, Y Wen, S Huang, X Yuan… - Frontiers in cell and …, 2021 - frontiersin.org
As the most abundant internal modification in eukaryotic cells, N6-methyladenosine (m6A) in
mRNA has shown widespread regulatory roles in a variety of physiological processes and …

[HTML][HTML] Molecular mechanisms of circular RNA translation

HJ Hwang, YK Kim - Experimental & Molecular Medicine, 2024 - nature.com
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs without a 5′ cap
structure and a 3′ poly (A) tail typically present in linear mRNAs of eukaryotic cells …