Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

Quantitative structure–activity relationship (QSAR) methods and related approaches have
been used to investigate the molecular features that influence the absorption, distribution …

Marine stickleback fish have colonized and adapted to thousands of streams and lakes
formed since the last ice age, providing an exceptional opportunity to characterize genomic …

Sulfotransferase-2A1 catalyzes the formation of bile acid-sulfates (BA-sulfates). Sulfation of
BAs increases their solubility, decreases their intestinal absorption, and enhances their fecal …

Despite the great promise of genetic code expansion technology to modulate structures and
functions of proteins, external addition of ncAAs is required in most cases and it often limits …

Introduction: Metabolism is one of the most important clearance pathways representing the
major clearance route of 75% drugs. The four most common drug metabolizing enzymes …

Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product.
The reactions catalysed include aromatisation, oxidation, reduction, sulfonation …

The sulfuryl transfer reaction is of fundamental biological importance. One of the most
important manifestations of this process are the reactions catalyzed by members of the …

Sulfur is present in the amino acids cysteine and methionine and in a large range of
essential coenzymes and cofactors and is therefore essential for all organisms. It is also a …

Adaptation is driven by natural selection; however, many adaptations are caused by weak
selection acting over large timescales, complicating its study. Therefore, it is rarely possible …