Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Cancer immunotherapy has been established as standard of care in different tumor entities.
After the first reports on synergistic effects with radiotherapy and the induction of abscopal …

Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …

Abstract Purpose of Review Cerebral radiation necrosis (CRN) is a major dose-limiting
adverse event of radiotherapy. The incidence rate of RN varies with the radiotherapy …

Brain metastases encompass nearly 80% of all intracranial tumors. A late stage diagnosis
confers a poor prognosis, with patients typically surviving less than 2 years. Poor survival …

Radiation‐induced brain necrosis (RBN) is a serious complication of intracranial as well as
skull base tumors after radiotherapy. In the past, due to the lack of effective treatment …

Stereotactic radiosurgery (SRS) is increasingly utilized to treat the resection cavity following
resection of brain metastases and recent randomized trials have confirmed postoperative …

Background Postoperative stereotactic radiosurgery (SRS) is a standard management
option for patients with resected brain metastases. Preoperative SRS may have certain …

Purpose Harmful effects of ionizing radiation on the Central Nervous System (CNS) are a
concerning outcome in the field of cancer radiotherapy and form a major risk for deep space …

Although intravenous bevacizumab (IVBEV) is the most promising treatment for cerebral
radiation necrosis (CRN), there is no conclusion on the optimal dosage. Our retrospective …