Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Drug combinations as a first line of defense against coronaviruses and other emerging viruses

JM White, JT Schiffer, RA Bender Ignacio, S Xu… - MBio, 2021 - Am Soc Microbiol
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

SB Biering, SA Sarnik, E Wang, JR Zengel, SR Leist… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

JM Flynn, N Samant, G Schneider-Nachum, DT Barkan… - Elife, 2022 - elifesciences.org
With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines …

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

SB Biering, FT Gomes de Sousa, LV Tjang… - Nature …, 2022 - nature.com
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the
lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory …

Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents

H Zarkoob, A Allué-Guardia, YC Chen… - Communications …, 2022 - nature.com
There is a critical need for physiologically relevant, robust, and ready-to-use in vitro cellular
assay platforms to rapidly model the infectivity of emerging viruses and develop new …

Gut microbiota of bats: pro-mutagenic properties and possible frontiers in preventing emerging disease

IV Popov, MS Mazanko, ED Kulaeva, SN Golovin… - Scientific reports, 2021 - nature.com
Bats are potential natural reservoirs for emerging viruses, causing deadly human diseases,
such as COVID-19, MERS, SARS, Nipah, Hendra, and Ebola infections. The fundamental …

Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection

SB Biering, SA Sarnik, E Wang, JR Zengel, V Sathyan… - BioRxiv, 2021 - biorxiv.org
SUMMARY SARS-CoV-2 can cause a range of symptoms in infected individuals, from mild
respiratory illness to acute respiratory distress syndrome. A systematic understanding of the …

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

X Nguyenla, E Wehri, E Van Dis, SB Biering… - Scientific reports, 2022 - nature.com
Abstract SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with
significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID …

[HTML][HTML] An In-silico investigation of potential natural polyphenols for the targeting of COVID main protease inhibitor

NH Aljarba, MS Hasnain, MM Bin-Meferij… - Journal of King Saud …, 2022 - Elsevier
The deadliest recent pandemic outbreak of COVID-19 disease has severely damaged the
socio-economic health of the people globally. Due to unavailability of any effective vaccine …