Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …

Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low
back pain, a leading cause of musculoskeletal disability worldwide. The major components …

Current treatments of degenerated intervertebral discs often provide only temporary relief or
address specific causes, necessitating the exploration of alternative therapies. Cell-based …

Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …

The circadian clock in mammals temporally coordinates physiological and behavioural
processes to anticipate daily rhythmic changes in their environment. Chronic disruption to …

Intervertebral disc degeneration (IVDD), a widely recognized cause of lower back pain, is
the leading cause of disability worldwide. A myriad of preclinical in vivo animal models of …

Circadian clocks in the brain and peripheral tissues temporally coordinate local physiology
to align with the 24 hours rhythmic environment through light/darkness, rest/activity and …

Scaffolds composed of synthetic, natural, and hybrid materials have been investigated as
options to restore intervertebral disk (IVD) tissue function. These systems fall short of the …

Intervertebral disc degeneration is considered a major cause of back pain that places a
heavy burden on society, both because of its effect on the physiology of individuals and its …