Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …

Xenopus embryos provide a rich source of pluripotent cells that can be differentiated into
functional organs. Since the molecular principles of vertebrate organogenesis appear to be …

Oesophageal atresia and/or tracheo-oesophageal fistula are relatively common
malformations occurring in approximately 1 in 3500 births. In around half of the cases …

Liver development requires two linked processes: differentiation of the various hepatic cell
types from their embryonic progenitors and the arrangement of those cells into structures …

The liver and pancreas arise from a common multipotent population of endoderm cells and
share many aspects of their early development. Yet each tissue originates from multiple …

The three phases of liver development that are the focus of this review are: the specification
of hepatoblasts within the endoderm, the lineage split of hepatoblasts into hepatocytes and …

How and when the vertebrate endoderm is first subdivided into discrete progenitor cell
populations that will give rise to the different major organs, including pancreas and liver, are …

While particular combinations of mesodermal signals are known to induce distinct tissue-
specific programs in the endoderm, there is little information about the response pathways …

Formation and function of the liver are highly controlled, essential processes. Multiple
signaling pathways and transcriptional regulatory networks cooperate in this complex …

Patterning of the embryonic endoderm into distinct sets of precursor cells involves the
precisely regulated activities of key transcription regulators. Ectopic, pan-endodermal …