This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

All cell and tissue types constantly release DNA fragments into human body fluids by various
mechanisms including programmed cell death, accidental cell degradation and active …

Background State‐of‐art non‐invasive diagnosis processes for bladder cancer (BLCA)
harbour shortcomings such as low sensitivity and specificity, unable to distinguish between …

Summary Background: Vascular endothelial cells (VECs) are an essential component of
each tissue, contribute to multiple pathologies, and are targeted by important drugs. Yet …

Epigenetic mechanisms such as DNA methylation (DNAme) are thought to comprise an
invaluable adaptive toolkit in the early stages of local adaptation, especially when genetic …

Cell-free DNA (cfDNA) are DNA fragments originating from dying cells that are detectable in
bodily fluids, such as the plasma. Accelerated cell death, for example caused by disease …

Background Circulating biomarkers for lung damage are lacking. Lung epithelium-specific
DNA methylation patterns can potentially report the presence of lung-derived cell-free DNA …

Programmed cell death, accidental cell degradation and active extrusion constantly lead to
the release of DNA fragments into human body fluids from virtually all cell and tissue types. It …

Deconvolution methods infer quantitative cell type estimates from bulk measurement of
mixed samples including blood and tissue. DNA methylation sequencing measures multiple …