[HTML][HTML] Towards the sustainable discovery and development of new antibiotics
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
[HTML][HTML] Update on the discovery of efflux pump inhibitors against critical priority Gram-negative bacteria
N Compagne, A Vieira Da Cruz, RT Müller… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …
[HTML][HTML] Drug efflux pump inhibitors: a promising approach to counter multidrug resistance in Gram-negative pathogens by targeting AcrB protein from AcrAB-TolC …
R Alenazy - Biology, 2022 - mdpi.com
Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …
negative bacteria, have posed serious health issues worldwide. Bacteria have different …
Fighting Antibiotic‐Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers
B Tse Sum Bui, T Auroy, K Haupt - … Chemie International Edition, 2022 - Wiley Online Library
Infections caused by antibiotic‐resistant bacteria are difficult and sometimes impossible to
treat, making them one of the major public health problems of our time. We highlight how …
treat, making them one of the major public health problems of our time. We highlight how …
[HTML][HTML] Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition
A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …
health threat worldwide due to significant morbidity and mortality resulting from their …
[HTML][HTML] Antibiotic adjuvants: Synergistic tool to combat multi-drug resistant pathogens
The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …
infectious disease treatment. To overcome this problem, novel strategies are being explored …
[HTML][HTML] Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
M Glavier, D Puvanendran, D Salvador… - Nature …, 2020 - nature.com
The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas
aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds …
aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds …
[HTML][HTML] Marine invertebrate antimicrobial peptides and their potential as novel peptide antibiotics
SV Guryanova, SV Balandin… - Marine drugs, 2023 - mdpi.com
Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic
environment and possess an effective defense system that has enabled their existence for …
environment and possess an effective defense system that has enabled their existence for …
[HTML][HTML] Massive analysis of 64,628 bacterial genomes to decipher water reservoir and origin of mobile colistin resistance genes: is there another role for these …
MB Khedher, SA Baron, T Riziki, R Ruimy, D Raoult… - Scientific reports, 2020 - nature.com
Since 2015, new worrying colistin resistance mechanism, mediated by mcr-1 gene has been
reported worldwide along with eight newly described variants but their source (s) and …
reported worldwide along with eight newly described variants but their source (s) and …
[HTML][HTML] The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs
S Chetri - Frontiers in Microbiology, 2023 - frontiersin.org
Efflux pumps function as an advanced defense system against antimicrobials by reducing
the concentration of drugs inside the bacteria and extruding the substances outside. Various …
the concentration of drugs inside the bacteria and extruding the substances outside. Various …