Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …

Pancreatic cancer is one of the most common causes of cancer death in the world due to the
lack of early symptoms, metastasis occurrence and chemoresistance. Therefore, early …

Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix
(ECM)-producing myofibroblasts, a phenotypes with multiple roles in hepatic fibrogenesis …

Abstract Background Circular RNAs (circRNAs) have been implicated in the development
and progression of gastric cancer (GC). However, it remains unclear whether dysregulated …

The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

Cancer immunotherapy has recently shown promising antitumor effects in various types of
tumors. Among all immune checkpoints, the PD-1/PD-L1 pathway plays an important role in …

Circular RNAs (circRNAs) are a class of single‐stranded RNAs with closed loop structures
formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; …

Circular RNA (circRNA) has been shown to be widely involved in a variety of lung diseases.
Cigarette smoke (CS) may induce epithelial-mesenchymal transition (EMT) of airway …

Highlights•Chronic exposure of mice to CS induces lung injury and fibrosis.•Exosomal miR-
21 mediates the CS-induced aberrant cross-talk of epithelium-fibroblasts.• …

Current treatment strategies for cancer, especially advanced cancer, are limited and
unsatisfactory. One of the most substantial advances in cancer therapy, in the last decades …