Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Innate immune receptors initiate a host immune response, or inflammatory response, upon
detecting pathogen-associated molecular patterns (PAMPs) and damage-associated …

Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases.
Accumulating evidence has shown that oxidative stress is characterized by the …

Dysregulated inflammasome activation contributes to respiratory infections and pathologic
airway inflammation. Through basic and translational approaches involving murine models …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

Cytosolic innate immune sensing is a cornerstone of innate immunity in mammalian cells
and provides a surveillance system for invading pathogens and endogenous danger …

Intracellular pathogens pose a significant threat to animals. In defense, innate immune
sensors attempt to detect these pathogens using pattern recognition receptors that either …