Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic
cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the …

Programmed cell death is a necessary part of development and tissue homeostasis
enabling the removal of unwanted cells. In the setting of infectious disease, cells that have …

Sepsis remains a major problem for human health worldwide, thereby manifesting high rates
of morbidity and mortality. Sepsis, once understood as a monophasic sustained …

Viral and microbial infections often elicit programmed cell death as part of the host defense
system or as a component of the survival strategy of the pathogen. It is thus not surprising …

Caspase-7 was considered to be redundant with caspase-3 because these related cysteine
proteases share an optimal peptide recognition sequence and have several endogenous …

Rationale: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host
response to infection, is a major public health concern with high mortality and morbidity …

The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial
sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 …

Rationale: Sepsis is one of the leading causes of death around the world. The failure of
clinical trials to treat sepsis demonstrates that the molecular mechanisms are multiple and …