Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …

The striatum plays a central role in guiding numerous complex behaviors, ranging from
motor control to action selection and reward learning. The diverse responsibilities of the …

Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …

The role of the striatum in motor control is commonly assumed to be mediated by the two
striatal efferent pathways characterized by striatal projection neurons (SPNs) expressing …

Extinction learning allows animals to withhold voluntary actions that are no longer related to
reward and so provides a major source of behavioral control. Although such learning is …

Learning valence-based responses to favorable and unfavorable options requires
judgments of the relative value of the options, a process necessary for species survival. We …

The striatum is a critical forebrain structure integrating cognitive, sensory, and motor
information from diverse brain regions into meaningful behavioral output. However, the …

Huntington's disease (HD) is an inherited neurodegenerative disorder that usually starts
during midlife with progressive alterations of motor and cognitive functions. The disease is …

Reward-processing impairment is a common symptomatic dimension of several psychiatric
disorders. However, whether the underlying pathological mechanisms are common is …

Key points Imbalances in the activity of the D1‐expressing direct pathway and D2‐
expressing indirect pathway striatal projection neurons (SPNs) are thought to contribute to …