Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in
which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the …

Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

The mitochondrial unfolded protein response (UPRmt) is essential to safeguard
mitochondria from proteotoxic damage by activating a dedicated transcriptional response in …

Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Mitochondrial fidelity is tightly linked to overall cellular homeostasis and is compromised in
ageing and various pathologies,–. Mitochondrial malfunction needs to be relayed to the …

Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …

Alzheimer's disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …